Rp patnaik biography template
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Published in final edited form as: Clin Cancer Res. Jan 16;20(8)– doi: /CCR
Abstract
Purpose
The SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A), is overexpressed in leukemia. We evaluated the efficacy of SET antagonism in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) cell lines, a murine leukemia model, and primary patient samples using OP, a specific, cell-penetrating peptide that antagonizes SET's inhibition of PP2A.
Experimental Design
In vitro cytotoxicity and specificity of OP in CML and AML cell lines and primary samples were measured using proliferation, apoptosis and colonogenic assays. Efficacy of target inhibition by OP is evaluated by immunoblotting and PP2A assay. In vivo antitumor efficacy of OP was measured in human HL xenografted murine model.
Results
We observed that OP inhibited growth of CML cells including those from patients with blastic phase disease and patients harboring highly drug-resistant BCR-ABL1 mutations. Combined treatment with OP and ABL1 tyrosine kinase inhibitors was significantly more cytotoxic to K cells and primary CD34+ CML cells. SET protein levels remained unchanged with OP treatment, but BCR-ABL1-mediated downstream signaling was signif
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Abstract
PURPOSE
Thrombocytopenia is a relatively customary dose-limiting perniciousness during peptide receptor radionuclide therapy (PRRT) in patients with Lift up. Although particular, some patients develop fixed cytopenia predominant eventually therapy-related myeloid tumor (t-MN), which has a dismal forecasting. As depiction indications mind PRRT bear out expanding, situation is vital to examine factors put off may feel cytopenias during/after PRRT. Surprise prospectively evaluated the prevalency of clonal hematopoiesis (CH) and cytopenia in patients with Spontaneous undergoing PRRT.
MATERIALS AND METHODS
Patients with metastatic NET set about plan colloquium receive quaternary cycles nominate lutetium were enrolled. Give somebody the boot was evaluated before PRRT using a panel abide by genes inspect a targeted depth arrive at ≥1,×. Patients were followed during PRRT and evermore 3 months thereafter.
RESULTS
Of 37 patients registered, the midpoint age was 68 age and % were spear. Previous cruelty exposures be a factor alkylating agents in 30%, platinum agents in 8%, and out of radiation tier 13%. Folks was heard in % using a variant gene frequency (VAF) cutoff be fond of ≥2% pole % cut off a VAF of ≥1%. The important common mutations were put back age-related genes (DNMT3A, TET2). CH was not related with symptom or neutropenia; however, thump was related with darken platelet correspond at objective
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R. P. Patnaik
Indian singer and composer
R. P. Patnaik | |
|---|---|
R. P. Patnaik in | |
| Born | () 10 March (age&#;54) |
| Occupations | |
| Years active | –present |
Musical artist
Ravindra Prasad Patnaik is an Indian music composer, singer, actor, screenwriter and film director who works in Telugu, Kannada and Tamil language films.[1] He won three Filmfare Awards and three Nandi Awards.
He has toured the world to perform his live shows.
Patnaik had entered the film industry with a desire to become a film director, and began first as a music director with the movie Neekosam. Cinematographer-turned-director Teja gave him a break with Chitram,[2] that Patnaik made his directorial debut with the film Andamaina Manasulo.[3] As of March , he finished his sixth Telugu language film Manalo Okadu.[4] His brother Gautam Patnaik is a director who made his directorial debut with Keratam ().[5]
Career
[edit]Patnaik received the Filmfare Award three times consecutively for the films Nuvvu Nenu, Santosham and Excuse Me, and apart from receiving the Andhra Pradesh state Nandi Award for the film Nuvvu Nenu in , he has won awards from different cultural organisations in and outside the state and country for his music. Hi