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Louie Henri (older)
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Cardio-renal epidemiology – Juan-Jesus Carrero's research group
Our research
Our research group focuses on cardio-renal epidemiology and pharmaco-epidemiology. We are a multidisciplinary team with expertise in several fields, including epidemiology, biostatistics, data science and medicine. Our research is based on large population-based and register data, including laboratory values and biopsies. We have several international and national collaborators in academia, health care, and industry.
We have four main projects ongoing at the moment:
Stockholm CREAtinine Measurements (SCREAM) project
SCREAM is an electronic health care data extraction of all residents of Stockholm since 2006. SCREAM contains longitudinal electronic health care records for more than 3,5 million people followed for a median of 12 years. For those that have at least one measurement of creatinine or albuminuria, we obtain a large list of laboratory tests. There are more than 2.2 million people with these measurements in the cohort.
SCREAM is linked to a range of national and regional databases collecting information on among other things primary health care consultations, dispensed medications, and quality registers of cardiovascular diseases, kidney diseases and dementia. 
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Abstract
Bacterial infections remain a significant global health concern, necessitating a comprehensive understanding of the intricate host−pathogen interactions that play a critical role in the outcome of infectious diseases. Recent investigations have revealed that noncoding RNAs (ncRNAs) are key regulators of these complex interactions. Among them, long noncoding RNAs (lncRNAs) have gained significant attention because of their diverse regulatory roles in gene expression, cellular processes and the production of cytokines and chemokines in response to bacterial infections. The host utilizes lncRNAs as a defense mechanism to limit microbial pathogen invasion and replication. On the other hand, some host lncRNAs contribute to the establishment and maintenance of bacterial pathogen reservoirs within the host by promoting bacterial pathogen survival, replication, and dissemination. However, our understanding of host lncRNAs in the context of bacterial infections remains limited. This review focuses on the impact of host lncRNAs in shaping host−pathogen interactions, shedding light on their multifaceted functions in both host defense and bacterial survival, and paving the way for future research aimed at harnessing their regulatory potential for clinical applications.
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