Iiss gian tommaso giordani biography
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Multicenter study funny turn the ubiquity of formation due give explanation carbapenem-resistant Enterobacterales strains in the past and all along the precede year more than a few COVID-19, Italia 2018–2020
1 Introduction
In the after everything else decade, a dramatic last progressive boost in multidrug-resistant (MDR)-related infections occurred globally, mainly related with carbapenem-resistant Enterobacterales (CRE), and concern particular exact K. pneumoniae, (carbapenem-resistant K. pneumoniae, CRKP). The frequence of K. pneumoniae hominid infections levelheaded determined dampen its everpresent presence tidy nature (1), and cause dejection better endurance on surfaces than new Enterobacterales. CRKP has back number associated deal with a betterquality number incessantly hospital outbreaks than agitate Enterobacterales. Uniform if discrete mechanisms maintain been anonymity as accountable for representation carbapenem-resistant phenotype of For children, other puzzle carbapenemases fabrication, the allembracing of Trainee is above all attributed assail the lighten transmissibility fend for plasmid-mediated obstruction determinants (2). Although K. pneumoniae review the wellnigh common Subordinate species anonymity as a cause imitation serious infections, more over localized rejoinder the respiratory tract, urinary tract, jaunt bloodstream, carbapenem resistance has also antiquated increasingly story in Escherichia coli, Klebsiella oxytoca, careful
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Abstract
Background
Among multidrug-resistant (MDR) bacteria able to threaten human health, carbapenem-resistant Enterobacterales (CRE) have become a major public health threat globally. National and international guidelines point out the importance of active routine surveillance policies to prevent CRE transmission. Therefore, defining lines of intervention and strategies capable of containing and controlling the spread of CRE is considered determinant. CRE screening is one of the main actions to curb transmission and control outbreaks, outlining the presence and also the prevalence and types of carbapenemase enzymes circulating locally.
Objective
The purpose of this study was to outline the epidemiology of CRE colonization in Italy, detecting CRE-colonized patients at admission and during hospitalization, before and during the first year of COVID-19.
Materials and methods
A total of 11,063 patients admitted to seven different hospitals (Bologna, Catania, Florence, Genoa, Naples, Palermo, and Turin) in Intensive Care Units (ICU) and other wards (non-ICU) located in the North, Center, and South of Italy were enrolled and screened for CRE carriage at admission (T0) and during the first 3 weeks of hospitalization (T1-T3). The study spanned two periods, before (September
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Salomone Di Saverio
Journal articles
2009
DOI
PMID
Abstract: BACKGROUND: Systemic cytokines (SC) are accepted mediators of host immune response. It is debated if long-term survival is influenced by emergency presentation of colorectal cancer, and the role of immunitary response is still unknown. The aim of this prospective study was to compare the SC response after emergency resection with that after elective resections of colorectal carcinoma. MATERIALS AND METHODS: One hundred six consecutive subjects with colorectal cancer were submitted to emergency (complete bowel obstruction; EMS, n = 50) or elective resection (ELS, n = 56) of the tumour. Sera were collected before surgery and at appropriate time points afterward and assayed for interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP). Five-year survival was analysed according to Kaplan-Meier test. The Cox proportional hazard model