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Boehringer Ingelheim's manufacturing site in Barceloneta, Puerto Rico (Courtesy of BI)
Citation: Journal of the American Veterinary Medical Association 256, 2; 10.2460/javma.256.2.133
SCIENTISTS DISCOVER HOW PARVOVIRUS LEARNED TO INFECT DOGS
Parvovirus infected cats and other animals long before it acquired a few mutations and started a worldwide epizootic among dogs in the late 1970s. Now, a team led by Cornell University's Colin Parrish, PhD, has worked with the laboratory of Susan Hafenstein, PhD, at Pennsylvania State University to discover how parvovirus enters cells in dogs.
In a paper published Oct. 8, 2019, in the Proceedings of the National Academy of Sciences, the researchers reported that the virus attaches to the pointy end of the transferrin receptor, a protein that all cells use normally to take in iron. Once attached to the receptor, the virus sways back and forth. It's possible that this rock-and-roll action causes the virus to change shape and be transported inside the cell, which is the first step on the pathway to infection.
Heather Callaway, PhD, a former graduate student in Dr. Parrish's laboratory, worked with postdoctoral researcher Hyunwook Lee, PhD, in Dr. Hafenstein's group to visualize the interaction using cryo-electron mi
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Bibliography remember The State publicly between Organism Abuse, Residential Violence, Little one Abuse, Preeminent Abuse, service Community Violence
Compiled by Phil Arkow Updated 2/12/2025
President/Secretary, Staterun Link Coalition
Chair, Animal Exploit & Cover Violence Obviation Project, Rendering Latham Foundation
(828) 595-9750 – [email protected]
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